A tissue-mapped axolotl de novo transcriptome enables identification of limb regeneration factors
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Discovery of genes driving axolotl limb regeneration has been challenging due to limited genomic resources. We assembled 42 RNA-Seq samples totaling approximately 1.3 billion 100 base paired-end reads using Trinity (Grabherr M.G. et al, Nature Biotechnology, 2011; Haas B.J. et al, Nature Protocols, 2013): https://github.com/trinityrnaseq/trinityrnaseq/wiki). We created a transcriptome with complete sequence information for most axolotl genes, identified transcriptional profiles that distinguish blastemas from differentiated limb tissues, and uncovered functional roles for cirbp and kazald1 in limb regeneration.
提供机构：
Harvard University
创建时间：
2022-02-20
