Metadata record for the manuscript: The CINSARC signature predicts the clinical outcome in patients with Luminal B breast cancer

<b>Summary</b><br> This metadata record provides details of the data supporting the claims of the related manuscript: “The CINSARC signature predicts the clinical outcome in patients with Luminal B breast cancer”. The related study tested the prognostic value for disease-free survival (DFS) of CINSARC, a multigene expression signature originally developed in sarcomas and shown to have prognostic impact in various cancers, in a series of 6035 early-stage invasive primary breast cancers. Type of data: prognostic value for DFS of CINSARC Subject of data: <i>Homo sapiens</i> Sample size: 6035 Population characteristics: All cases were invasive breast carcinomas profiled using DNA microarrays or RNA-sequencing with expression and clinicopathological data available. All samples are pre-treatment samples (operative specimen or diagnostic biopsy before neo-adjuvant chemotherapy). The detailed characteristics of patients and tumours analysed in the present study are available in Supplementary Table 10. Recruitment: publicly available transcriptomic data of invasive primary breast cancer enrolled in 36 retrospective studies published over a 10-year period between 2002 and 2012. <b>Data access</b> All data sets of primary breast cancer were downloaded from the Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/), ArrayExpress (https://www.ebi.ac.uk/arrayexpress/), Genomic Data Commons (GDC, https://portal.gdc.cancer.gov/) and cBioPortal (https://www.cbioportal.org/) databases. All accession IDs are provided in Supplementary Table 10 (Table S10 revised.xlsx), which is included with this data record. The data underlying the figures and tables of the related article are contained in the files ‘Goncalves_supporting_data.xlsx’ and ‘Table S8.xlsx’, which are included with this data record. A detailed list of the data underlying each figure and table of the related article is available in the file ‘Goncalves_2021_underlying_data_list.xlsx’, which is included with this data record. <b>Corresponding author(s) for this study</b> Pr François BERTUCCI, MD PhD, Département d’Oncologie Médicale, Institut Paoli-Calmettes, 232 Bd. Ste-Marguerite, 13009 Marseille, France e-mail:[e-mail] ; Phone : [phone] ; Fax : [phone] <br> <b>Study approval </b> The details of Institutional Review Board and Ethical Committee approval and patients’ consent for the 36 studies analysed in the related study are present in their corresponding publications, which are listed in Supplementary Table 10 of the related article.