Gut-microbiota-brain axis involves in the neuroprotection of phosphoglycerate mutase 5 deficiency in traumatic brain injury mice

Male Pgam5 KO mice consistently exhibited increased abundance of the A. muciniphila. The FMT treatment was better able to maintain amino acid metabolism and a more hospitable environment in the periphery than in the TBI-vehicle group. Treatment of FMT male Pgam5-/- mice suppressed inflammatory factors and neuronal damage and improved neurological deficits following TBI, and A. muciniphila was negatively related with intestinal mucosal injury and neuroinflammation after TBI