quercusTOA database: Integrating functional annotations and comparative genomics across oak lineages

· QuercusTOA is a comprehensive database integrating curated records of Quercus proteins with taxonomic, functional, and structural information. It provides a robust framework for comparative genomics and functional analysis across several oak species and model organisms. The database is organized into three core datasets: Sequence Dataset: Contains genomic and proteomic data for Q. suber, Q. robur, Q. lobata, Q. rubra, Q. variabilis, Q. dentata, Q. gilva, Q. longispica, and Q. acutissima. Data were integrated from NCBI, CNCB-NGDC, TAIR10, and CANTATA lncRNA databases using the NGShelper toolset. Comparative Genomics Dataset: Features gene and CDS relationships established via MMseqs2 clustering and Liftoff. It includes homology mapping between Quercus species and cross-species protein relationships. Functional Annotation Dataset: Provides high-quality consensus sequences (validated by BUSCO) and annotations derived from InterProScan and eggNOG-mapper. It also includes A. thaliana orthologs and BLAST+/Diamond databases for rapid sequence search. Access A dynamic version of QuercusTOA is hosted by CESVIMA (UPM) and can be accessed via the official website or the QUERCUSTOA-APP.