Supplementary Material for: Clinicopathological characteristics and outcomes of patients with crescentic lupus nephritis

Background：Crescentic lupus nephritis (cLN) is an uncommon and severe phenotype in LN with limited data on outcomes and relevant risk factors. Methods: Eighty-three cases of biopsy-proven LN with ≥50% crescents were included. Another 83 non-crescentic LN patients with 50% were identified as risk factors for ESRD in cLN patients. Elevated serum creatinine level at baseline was a risk factor for death in cLN patients. Conclusions: cLN patients had worse treatment response and renal outcomes than non-cLN but the mortality risk was similar. The presence of wire loop lesions and renal tubular atrophy>50% on renal biopsy may predict ESRD in cLN patients.