Effect of iron exposure on the gene expression profile of human brain vascular pericytes.

We hypothesize blood breakdown products present after hemorrhage to be inducers of brain edema via the ferroptosis-induced cell death of pericytes leading to comprimised blood-brain-barrier. RNAseq was applied to investigate the intracellular response of pericytes to iron exposure from cerebral hemorrhage. Differential gene expression analysis of RNA-seq data for pericytes treated with Ammonium iron (II) sulfate hexahydrate (AE2S) or iron (III) chorid (FeCl3) compared with medium only.