Genome-wide DNA methylation proifling reveals candidate biomarkers and probable molecular mechanisms in metabolic syndrome [RNA-seq]

The goals of this study are to investigate the molecular mechanism and biomarker by DNA methylation profiles in patients with metabolic syndrome compared to normal. Overall design: In this study, we performed Infinium MethylationEPIC BeadChIP and RNA-seq with same patients to explore a molecular targets for the prediction of metabolic syndrome. A total of 20 participants, including 11 patietns with metabolic syndrome and 9 normal were enrolled in our study.