Evidence of Desulfurization in the Oxidative Cyclization of Thiosemicarbazones. Conversion to 1,3,4-Oxadiazole Derivatives

The addition of pyridine-2-carbaldehyde 4N-methylthiosemicarbazone (C8H10N4S) to an aqueous solution of copper(II) nitrate yields
[{Cu(C8H9N4S)(NO3)}2] (1). This complex consists of centrosymmetric dinuclear entities containing square-pyramidal copper(II) ions
bridged through the sulfur thioamide atoms. The oxidation of 1
with KBrO3 or KIO3 gives rise to a compound with formula [{Cu(C8H8N4O)(H2O)2(SO4)}2]·2H2O (2) (C8H8N4O = 2-methylamino-5-pyridin-2-yl-1,3,4-oxadiazole). The structure of 2 is made up of
centrosymmetric dimers where the copper(II) ions exhibit a distorted
octahedral coordination and are connected by the oxadiazole
moiety. The metal ions in 2 can be removed by addition of
K4[Fe(CN)6], and then the oxadiazole ligand can be isolated and
recrystallized as (C8H8N4O)·3H2O (3).