Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus

Transcriptomic profile of rat choroid plexus (whole tissue) of both male and female sex, epithelial cells captured by fluorescence-activated cell sorting (FACS), and compared to proximal tubules of the kidneys. The transcriptomic profile of choroid plexus displays high similarity between sex and choroid plexus epithelial cells, and lesser similarity to another secretory epithelium, the proximal tubules. The analysis provides an insight into transport mechanisms that could participate in CSF secretion and suggest regulatory candidates.本数据集涵盖雌雄两性大鼠脉络丛（choroid plexus）全组织的转录组谱（transcriptomic profile），其中脉络丛上皮细胞通过荧光激活细胞分选（fluorescence-activated cell sorting, FACS）分离捕获，并与肾脏近端小管（proximal tubules）进行对照分析。脉络丛的转录组谱在不同性别及脉络丛上皮细胞间展现出高度相似性，而与另一种分泌上皮——肾脏近端小管的相似性相对较低。本分析为参与脑脊液（cerebrospinal fluid, CSF）分泌的转运机制提供了新的研究视角，并提出了潜在的调控候选靶点。