The presence of odd-chain fatty acids in <i>Drosophila</i> phospholipids

Most fatty acids in phospholipids and other lipid species carry an even number of carbon atoms. Also odd-chain fatty acids (OCFAs), such as C15:0 and C17:0, are widespread throughout the living organism. However, the qualitative and quantitative profiles of OCFAs-containing lipids in living organisms remain unclear. Here, we show that OCFAs are present in <i>Drosophila</i> phosphatidylcholine (PC) and phosphatidylethanolamine (PE) and that their level increases in accordance with progression of growth. Furthermore, we found that food-derived propionic acid/propanoic acid (C3:0) is utilized for production of OCFA-containing PC and PE. This study provides the basis for understanding <i>in vivo</i> function of OCFA-containing phospholipids in development and lipid homeostasis. Food-derived propionic acid is utilized for production of OCFA-containing phosphatidylcholine (PC) and phosphatidylethanolamine (PE) in <i>Drosophila</i>.磷脂及其他脂质种类中的多数脂肪酸均带有偶数个碳原子。而奇数链脂肪酸（odd-chain fatty acids, OCFAs），如C15:0与C17:0，则广泛存在于各类生物体中。然而，目前学界对生物体中含OCFA脂质的定性与定量分布特征仍不明晰。本研究证实，果蝇（Drosophila）体内的磷脂酰胆碱（phosphatidylcholine, PC）与磷脂酰乙醇胺（phosphatidylethanolamine, PE）中均含有OCFA，且其含量随机体生长进程逐步升高。进一步研究发现，食物来源的丙酸（propionic acid/propanoic acid, C3:0）可被用于合成含OCFA的PC与PE。本研究为解析含OCFA磷脂在生物体发育与脂质稳态中的体内（in vivo）功能提供了理论基础。在果蝇体内，食物来源的丙酸可用于合成含OCFA的磷脂酰胆碱与磷脂酰乙醇胺。

搜集汇总

背景与挑战

背景概述

该数据集聚焦于果蝇磷脂中奇数碳链脂肪酸（OCFAs）的存在与功能，揭示了OCFAs（如C15:0和C17:0）在果蝇磷脂酰胆碱和磷脂酰乙醇胺中的分布，并发现其水平随生长增加，且食物来源的丙酸是OCFAs合成的关键前体。数据集提供了原始实验数据（如7个PDF文件），支持对OCFAs在发育和脂质稳态中体内功能的理解，涉及生物化学、遗传学等多学科领域。