We propose to establish the budding yeast as a model for human GWAS populations. We have previously generated an artificially outbred S. cerevisiae population by crossing four founder strains represen
How have extracellular proteases evolved among yeasts? In addition to having active proteases Candida caseinolytica is one of the earliest diverging members of the Saccharomycotina. This taxon that is
One clear hallmark of mammalian promoters is the presence of CpG islands (CGIs) at more than two thirds of genes whereas TATA boxes are only present at a minority of promoters. Using genome-wide appro
