Relative in vitro inhibition of Top1 by CPT, hCPT, and derivatives.
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Modified A-ring ring positions (10, 11) and E-ring position (20) are indicated for CPT/hCPT derivatives; modifications shown in italics (see Fig. 1 for CPT and hCPT structures).*As reported by Laco et al. [15], [16].**As reported by Wang et al. for racemic CPT derivatives [20]. All Top1 inhibition assays were performed using an end-labeled dsDNA oligonucleotide.
创建时间：
2015-12-02
