PROGNOSTIC SIGNIFICANCE OF CYTOKINE PROFILE AND NEUROIMAGING MARKERS IN THE PROGRESSION OF PARKINSON'S DISEASE

This scientific study analyzed 175 individuals, including 155 patients diagnosed with Parkinson's disease and 20 healthy controls, focusing on clinical subtypes (tremor-dominant, akinetic-rigid, and mixed forms). The research evaluated immunological (IL-1β, IL-6, TNF-α, IL-10), psychological (HADS, MMSE, VFT), and neurovisual (MRI) parameters. Results demonstrated significant differences in cytokine levels and cognitive-emotional status across subtypes. The findings underline the importance of a multidisciplinary approach to the diagnosis, classification, and personalized management of Parkinson’s disease.