Transcriptomic analysis of head and neck cancer stable cell lines [RNA-seq_HU]

Gain-of-function mutant p53 can function through a mutp53-MCM5-Sting-noncanonical NFkB siganling axis. We will analyze the transcriptional profils of head and neck cancer stable cell lines UM-SCC-1 and MDA1586 with overexpression or downregulation of mutant p53 in the presence or absence of Sting or RelB knockdown under the treatment with or without hydroxyurea. Total RNA extraction from UM-SCC-1 stable cell lines treated with hydroxyurea were used for RNA-seq.