Ion Channel-like Crystallographic Signatures in Modified Guanine–Potassium/Sodium Interactions

This communication describes crystallographic details
of structures
reminiscent of ion channels, formed from regioisomeric N7 and N9 guanine-carboxylate
conjugates with potassium/sodium ions and their subsequent STM observations
on Au(111) surface. Ion channel-like crystal structures were obtained
with the observation of a notable shift in metal ion coordination
from carbonyl to carboxylate oxygen. These results are expected to
provide insight into competing sites for modified guanine–metal
coordination, an entry into guanine-based ion channels and a route
toward guanine-functionalized surfaces.

本篇通信阐述了类似离子通道结构的晶体学细节，这些结构由区域异构的N7和N9鸟嘌呤羧酸盐共轭物与钾/钠离子构成，并在金(111)表面进行了随后的扫描隧道显微镜（STM）观测。通过观察金属离子配位从羰基氧向羧酸盐氧的显著偏移，获得了类似离子通道的晶体结构。这些结果有望揭示修饰鸟嘌呤-金属配位的竞争位点、鸟嘌呤基离子通道的入口以及构建鸟嘌呤功能化表面的途径。