The metallic compound promotes primordial follicle activation and ameliorates fertility deficits in aged mice. The metallic compound promotes primordial follicle activation and ameliorates fertility deficits in aged mice

We found MnCl2 and ZnSO4 promoted the activation of mouse primordial follicles through glycosis-dependent mTOR pathway in granulosa cells and PI3K/Akt pathway in oocytes. We further analyzed the transcriptome changes in the ovaries after MnCl2 and ZnSO4 treatments. Overall design: Comparative gene expression profiling analysis of RNA-seq data for the 1-day cultured ovaries between the control group (Ct) and the MnCl2 (Mn) or ZnSO4 (Zn) group.