Gene expression profile at single cell level of vestibular schwannoma

Vestibular schwannoma (VS) is the most common benign tumor in the cerebellopontine angle and internal auditory canal. Illustrating the heterogeneous cellular components of VS could provide insights into its various growth patterns. Single-cell RNA sequencing (scRNA-seq) was used to profile transcriptomes from 7 VS samples and 2 great auricular nerves as normal control. Seven patients diagnosed with sporadic VS who had undergone surgery at our clinic were included. Two normal great auricular nerves was collected from patients with trauma during debridement surgery. In total, nine fresh surgical specimens were sequenced and analyzed.