Baseline characteristics of included patients.

*These comparisons between HCC cases and controls are statistically significant (P<0.05). Repl, replication. The cohort labeling “Japanese GWAS” and “Japanese Replication” is based on the initial description of the cohorts in Miki et al., for the present study both cohorts served as replication cohorts.
1Age and sex data was missing in 5 patients in the Bonn/Berlin cohort. For the SCCS, age of infection is shown. Age of infection was unknown for the Bonn/Berlin cohort, for this cohort age at diagnosis is shown.
2Alcohol consumption data was missing in 12 HCC and 290 non-HCC patients from the SCCS.
3HCV genotype was missing in 5 HCC and 23 non-HCC patients from the SCCS, in 1 HCC and 2 non-HCC patients from the Japanese GWAS, and 50 HCC patients from the Japanese replication cohorts.