Numbers of DMRs identified by MeDIP-seq, and assignment to subgenomic regions.

In total 6123 500 bp-windows met criteria for hypermethylation in adenoma and resulted in 5135 merged hypermethylated DMRs; 11567 500 bp-windows were identified as hypomethylated in adenoma and resulted in 8845 merged hypomethylated DMRs; on average, hypomethylated DMRs were larger compared to hypermethylated regions.CGI, CpG island; Pro, Promoter (−1 kb to +0.5 kb of the TSS); CGI-Pro, Promoter containing CpG island, Exon-Pro, Promoter-to-exon junction; Vert. Cons., conserved vertebrate elements. Repeats were identified using the Repeat Masker table and conserved elements using the conserved Vertebrate phastconsElements30way table provided by UCSC [60].