RNA-Seq Analysis of Wild Type and LGMN-/- Peritoneal Macrophage Transcriptomes.
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Research on the interaction between tumour-associated macrophages (TAMs) and tumour cells has generated great interest in the potential use of macrophages as a therapeutic strategy against tumour cells. Here, we show that deletion of legumain, a conversed proteolytic enzyme in macrophages, promotes senescence of macrophages and tumour cells. Peritoneal macrophages isolated from wide type and lgmn-/- mice were co-cultured with EO771 breast cancer cells for 4 days. Total RNA was extracted for RNA-Seq analysis, cDNA library construction and sequencing were performed using BGISEQ-500 platform.
提供机构：
School of Basic Medical Sciences, Tianjin Medical University
创建时间：
2022-02-20
