Common variants in candidate genes associated with serum lipids in African Americans (n = 1694).

Abbreviations: Additive (Add), Chromosome (Chr), Dominant (Dom), Minor Allele Frequency (MAF), High-density Lipoprotein Cholesterol (HDLC), Recessive (Rec), Log-transformed Triglycerides (logTG); 1Build 37 position; 2 βs are given for the minor (“Alt”) allele. TG values were log-transformed: β values represent the percent change in TG. 3Correction for multiple hypotheses conducted by calculating the effective degrees of freedom using the covariance matrix for variants in each gene. All P-values have been multiplied by the effective degrees of freedom for that gene (see methods and reference[54]); 4Similar results observed for the following CVs in high LD (R2>0.8) with listed SNP: rs114851717 (rs138618449, rs148714575, rs115761095, rs76729624), rs256 (rs271), rs328 (rs325, rs117199990, rs145391587, rs75278536, rs77069344, rs11570891, rs1803924, rs3735964), rs1059611 (rs149865365), rs2515602 (rs2472386), rs1800977 (rs2437817, rs2243312).CVs in LD (R2>0.6); 5These associations would no longer be statistically significant if adjusted for model selection (4 genetic models compared).