Luminescent Detection of Colchicine by a Unique Indium–Organic Framework in Water with High Sensitivity

Colchicine
is highly toxic to creatures, and sensitively detecting
colchicines is of profound significance in the pharmaceutical, clinical,
food, and breeding industries. We herein designed and constructed
a unique luminescent indium–organic framework {[(CH3)2NH2]­[In­(L)]·9DMF}n (V105) via an in situ ligand-mediated method,
which possesses a 2-fold interpenetrated 3D anionic framework. Due
to the large channels that exist in the framework with the size of
12 Å × 14 Å, V105 can rapidly remove harmful
cationic dyes from water in a few minutes. Importantly, luminescent
experiments demonstrate that V105 can selectively detect
colchicine with high sensitivity in water, and the limit of detection
can reach 1.0 × 10–7 M. To our knowledge, this
is the first example of a metal–organic framework-based luminescent
sensor for detecting colchicine.