Spatial transcriptomic comparison between IPF and donor lung distal explant tissue

Pulmonary fibrosis remains a significant public health concern due to an increasing incidence and limited treatment options. Alveolar type 2 epithelial cell (AT2) senescence causes stem cell exhaustion and progenitor failure, leading to ineffective and aberrant alveolar repairs and unresolved fibrosis. AT2 senescence regulatory molecules require additional studies. The spatial transcriptomics study we present here is aiming to comparing end stage IPF explant tissue with donor distal tissue to better understand the molecular changes associated with diseases. Overall design: 3 donor explant samples vs 2 IPF explant samples are subjected to 10x visium spatial analysis