AS1411-conjugated doxorubicin-loaded silver nanotriangles for targeted chemo–photothermal therapy of breast cancer - supplementary data

Background: Combination therapy has attracted tremendous interest for its great potential in treating cancers. Materials & methods: Based on chitosan-coated silver nanotriangles, polyethylene glycol, AS1411 aptamer and doxorubicin, a multifunctional nanocomposite (AS1411-DOX-AgNTs) was constructed and characterized. Then the photothermal properties, ability to target breast cancer cells and anti-breast cancer effect of AS1411-DOX-AgNTs were evaluated. Results: AS1411-DOX-AgNTs were successfully fabricated and showed excellent photothermal conversion efficiency, breast cancer cell and tumor targeting ability. Compared with single treatments, the combination of AS1411-DOX-AgNTs with nearinfrared irradiation possessed the strongest anti-breast cancer effect in vitro and in vivo. Conclusion: AS1411-DOX-AgNTs hold great potential in targeted DOX delivery and combined chemo–photothermal therapy for breast cancer.

背景：联合治疗因其治疗癌症的巨大潜力而备受关注。材料与方法：基于壳聚糖包覆的银纳米三角片、聚乙二醇、AS1411适配体和阿霉素，构建并表征了一种多功能纳米复合材料（AS1411-DOX-AgNTs）。随后，评估了AS1411-DOX-AgNTs的 photothermal特性、靶向乳腺癌细胞的能力及其抗乳腺癌效应。结果：成功制备了AS1411-DOX-AgNTs，并显示出卓越的光热转换效率、靶向乳腺癌细胞和肿瘤的能力。与单一治疗方法相比，AS1411-DOX-AgNTs与近红外照射的结合在体外和体内均展现出最强的抗乳腺癌效应。结论：AS1411-DOX-AgNTs在靶向阿霉素递送和联合化疗-光热疗法治疗乳腺癌方面具有巨大的潜力。