An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development
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Two variants (rs2069837, and rs13306435) in the IL-6 gene were identified and genotyped from 566 patients with ONFH and 566 healthy controls. The associations between IL-6 polymorphisms and ONFH susceptibility were assessed using odds ratio (OR) and 95% confidence interval (95% CI) via logistic regression. The results of the overall analysis revealed that IL-6 rs2069837 is correlated with decreased risk of ONFH among the Chinese Han population (<em>p</em> < 0.05). In stratified analysis, rs2069837 also reduced the susceptibility to ONFH in older people (> 51 years), males, nonsmokers, and nondrinkers (<em>p</em> < 0.05).
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Zenodo创建时间：
2021-09-02
