Phospholipase C-mediated cascade; FGFR4

Phospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 domain) of PLC-gamma and of other signaling molecules (such as GTPase-activating protein and phosphatidylinositol 3-kinase-associated p85) direct their binding toward autophosphorylated tyrosine residues of the FGFR. Recruitment of PLC-gamma results in its phosphorylation and activation by the receptor. Activated PLC-gamma hydrolyzes phosphatidyl inositol[4,5] P2 to form the second messengers diacylglycerol (DAG) and Ins [1,4,5]P3, which stimulate calcium release and activation of calcium/calmodulin dependent kinases.<br>

磷脂酶C-γ（PLC-γ）是成纤维细胞生长因子受体（FGFR）及其他酪氨酸激酶活性受体的底物。已知PLC-γ及其他信号分子（如GTP酶激活蛋白和磷脂酰肌醇3激酶相关的p85）的src同源区2（SH2结构域）引导其与FGFR的自身磷酸化酪氨酸残基结合。PLC-γ的募集导致其被受体磷酸化和激活。激活的PLC-γ水解磷脂酰肌醇[4,5]P2，生成第二信使二酰甘油（DAG）和Ins[1,4,5]P3，这些物质可刺激钙离子释放和钙/钙调蛋白依赖性激酶的激活。