Tables S2-S3. SMR-HEIDI results for 8q24.21 locus between back pain and other phenotypes.

Supplementary Table S2. SMR-HEIDI results for 8q24.21 locus between back pain and other complex traits.

Column headers of Tables S2:

Secondary Trait Name: Name of complex trait
Dataset: Name of dataset (UKB Neale's lab or UKB Gene Atlas)
Index_SNP: RsID of SNP used as target in SMR-HEID analysis
Proxy_SNP: RsID of top SNP in the selected locus - SNP presented in both GWAS data with minimum P-values in back pain GWAS
r(proxy_SNP,index_SNP): linkage disequilibrium coefficient  between index and proxy SNP
beta_SMR: Beta SMR for proxy SNP
p_SMR: P-value of beta SMR
qFDR-BH SMR:  P-value of beta SMR after Bonferroni correction
p_HEIDI: P-value of HEIDI test
n_HEIDI: Number of SNPs used in HEIDI test
SNPs_HEIDI: List of rsID of SNPs used in HEIDI test

Supplementary Table S3. SMR-HEIDI results for 8q24.21 locus between back pain and expression of genes.

Column headers of Tables S3:

Secondary Trait Name: Name of complex trait
Tissue: Name of the tissue from which the samples were taken to study gene expression
Gene_name: Gene name corresponding to the transcript name
Transcript Name: Transcript name (ID)
Dataset: Name of dataset (CEDAR, GTEx_v6)
beta_SMR: Beta SMR for proxy SNP
p_SMR: P-value of beta SMR
qFDR-BH SMR: P-value of beta SMR after Bonferroni correction
p_HEIDI: P-value of HEIDI test
n_HEIDI: Number of SNPs used in HEIDI test
SNPs_HEIDI: List of rsID of SNPs used in HEIDI test

Part of the article: Williams FMK et al. "Sequence variation at 8q24.21 and risk of back pain"