Crystal structure of HCV NS5B polymerase in complex with coupound 1
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Crystal structure of HCV NS5B polymerase in complex with coupound 1 Descriptor: 1-(2,4,6-trifluorobenzyl)-6-[2-(trifluoromethyl)phenoxy]quinazolin-4(1H)-one, GLYCEROL, Genome polyprotein, ... Authors: Coulombe, R. Deposit date: 2013-03-24 Release date: 2013-07-10 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (3 Å) Cite: Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. J.Med.Chem., 57, 2014
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2013-03-24
