Additional file 1 of Distinct patterns of whole blood transcriptional responses are induced in mice following immunisation with adenoviral and poxviral vector vaccines encoding the same antigen

Additional file 1: Supplementary Figure 1. Overlap between significantly differentially expressed genes (DEGs) in mouse whole blood 24 h after immunisation with human adenovirus serotype 5 (HuAd5) encoding a bacterial (factor H binding protein, Ad-fHbp), viral (pre-fusion F protein, Ad-preF), or no antigen (Ad-empty) and a modified vaccinia Ankara (MVA) virus encoding fHbp. Significantly DEGs were defined as those with an FDR < 0.01. Genes unique to each vaccine group represent putative transgene-encoded antigen-specific genes, while genes in the intersection between all three groups adenovirus groups represent HuAd5 vector-specific genes. Genes overlapping between Ad-fHbp and MVA-fHbp are highlighted as these serve as confirmation of the ability to detect a transgene product-specific gene signature from each vaccine platform. Supplementary Table 1. Ad-empty gene ontology over-representation analysis results. Supplementary Table 2. Ad-fHbp gene ontology over-representation analysis results. Supplementary Table 3. Ad-preF gene ontology over-representation analysis results. Supplementary Table 4. MVA-fHbp gene ontology over-representation analysis results. Supplementary Table 5. Ad-fHbp prime MVA-fHbp boost gene ontology over-representation analysis results. Supplementary Table 6. MVA-fHbp prime Ad-fHbp boost gene ontology over-representation analysis results. Supplementary Table 7. Ad-empty pathway over-representation analysis results. Supplementary Table 8. Ad-fHbp pathway over-representation analysis results. Supplementary Table 9. Ad-preF pathway over-representation analysis results. Supplementary Table 10. MVA-fHbp pathway over-representation analysis results. Supplementary Table 11. Ad-fHbp prime MVA-fHbp boost pathway over-representation analysis results. Supplementary Table 12. MVA-fHbp prime Ad-fHbp boost pathway over-representation analysis results.