Sickle Cell Disease Exomes. Homo sapiens

Although all Sickle Cell Disease (SCD) patients have the same A to T mutation at position 6 of the beta-globin gene, some patients have mild disease and others have severe disease. The goal of this project is to define variations in genes that predispose SCD patients to stroke and other severe outcomes. When these variations are defined, the information can be used to identify patients who have a high probability of developing severe disease.