Unwinding DNA for the nascent transcript

The human BTF2 basic transcription factor (also called TFIIH), is required for class1 gene transcription of transcripts. TFIIH has an adenosine triphosphate-dependent DNA helicase activity. The helicase activity is closely associated with the multi-subunit BTF2/TFIIH transcription factor which also has a CTD protein kinase activity.

人类BTF2基本转录因子（亦称TFIIH）对于转录本的第一类基因转录至关重要。TFIIH具备依赖于三磷酸腺苷的DNA解旋酶活性。该解旋酶活性与多亚基的BTF2/TFIIH转录因子紧密相关，后者亦具备CTD蛋白激酶活性。