Alcohol dependence in rats is associated with global changes in gene expression in the central amygdala

Here, we examined the effects of alcohol on global gene expression in the CeA using a chronic intermittent ethanol (CIE) vapor model in rats and RNA sequencing (RNA-Seq). The CIE procedure resulted in robust changes in CeA gene expression during intoxication; as the number of differentially expressed genes (DEGs) was significantly greater than those expected by chance. Over-representation analysis of cell types; functional groups and molecular pathways revealed biological categories potentially important for the development of alcohol dependence in our model. Overall design: Studying the effects of Chronic alcohol exposure effects on global gene expression in the Central Nucleus of the Amygdala.