Interferon type I signaling pathways

The type I IFNs (IFNα family, IFNβ, IFNω, IFNε and IFNκ) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other accessory proteins. The pathway above (WP585) describes the Type I Interferon signaling pathways and shows both classical IFN signaling via the JAK-STAT pathway (dark lines) and other non-canonical IFN signaling pathways.

I型干扰素（包括IFNα家族、IFNβ、IFNω、IFNε和IFNκ）均能与I型干扰素受体复合物结合并传递信号。I型受体主要由两个主要的IFNAR1、IFNAR2c受体链和其他辅助蛋白组成。上述通路（WP585）描述了I型干扰素信号通路，并展示了经典通过JAK-STAT通路（深色线条）进行的干扰素信号传导以及其他非典型干扰素信号传导途径。