The SLE transcriptome exhibits evidence of chronic endotoxin exposure and has widespread dysregulation of non-coding and coding RNAs. Homo sapiens

We utilized next generation sequencing of transcripts (RNA-seq) to characterize the SLE transcriptome in monocytes.This is the first RNA-seq study of SLE using clinical subjects and we found a transcriptome that exhibits quantitative alterations as defined by the level of gene expression but also qualitative differences with widely altered splicing preference and non-coding RNA transcription. Overall design: total RNA from 8 heathy controls and 9 SLE patients were used to RNA sequence and comparision the whole transcriptome alteration