Mouse transcriptome of two genetic mutations of Grm1

We report two genetic mutations of GRM1, which are Grm1-S458A and Grm1b-R889W, identified from two natural short sleep families. The introduction of these mutations into mouse models also causes the mice to sleepless. Thus, these findings suggest GRM1 is another short sleep gene and highlight the essential roles of mGluRs in regulating human sleep. Hippocampus transcriptome of four wildtype (WT) mice, four Grm1-S458A mice, and four Grm1b-R889W mice.