Cancer Cell Cytotoxicity of Cyclometalated Compounds Obtained with Osmium(II) Complexes
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https://figshare.com/articles/dataset/Cancer_Cell_Cytotoxicity_of_Cyclometalated_Compounds_Obtained_with_Osmium_II_Complexes/2438044
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资源简介：
A library
of 29 organoosmium compounds has been built up with known and novel
cyclometalated compounds obtained with C–N, N∧C∧N, and C∧N∧N ligands. All compounds have been tested for their in vitro cytotoxic
properties against A172, a tumor cell line derived from a human glioblastoma,
this affording a contrasted picture of the activities of the compounds
gathered in this study. Some compounds displayed good to excellent
activities, some of them showing IC50 in the nanomolar
range. The level of activity was tentatively correlated to several
physicochemical properties of the compounds such as their E01/2(OsIII/II) redox potential
and their lipophilicity (log Po/w). A
parallel with related ruthenium derivatives was tentatively proposed.
创建时间：
2013-03-04
