RNA-seq of A2780 cells treated with resveratrol

Ovarian cancer (OC) is one of the most common malignant gynecological cancers. This study explored the effects of resveratrol (RES) on OC cell proliferation and apoptosis. A2780 cells treated with different concentrations of RES for 24h.RNA sequencing (RNA-seq) was performed to analyze the circular RNA (circRNA), microRNA (miRNA), and messenger RNA (mRNA)expression spectrum.The differentially expressed genes included 460 circRNAs, 1988 miRNAs and 1671 mRNAs, and were subjected to Gene Ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG) and Reactome enrichment analyses. We selected signaling pathways enriched in the cell processes by mRNA KEGG, comprehensively analyzed the circRNA-miRNA-mRNA regulatory network. The circRNA-miRNA-mRNA regulatory network we constructed provides new insights into the ability of RES to inhibit cell proliferation and promote apoptosis in A2780 cells.