European Nucleotide Archive

The European Nucleotide Archive (ENA) captures and presents information relating to experimental workflows that are based around nucleotide sequencing. A typical workflow includes the isolation and preparation of material for sequencing, a run of a sequencing machine in which sequencing data are produced and a subsequent bioinformatic analysis pipeline. ENA records this information in a data model that covers input information (sample, experimental setup, machine configuration), output machine data (sequence traces, reads and quality scores) and interpreted information (assembly, mapping, functional annotation). Data arrive at ENA from a variety of sources. These include submissions of raw data, assembled sequences and annotation from small-scale sequencing efforts, data provision from the major European sequencing centres and routine and comprehensive exchange with our partners in the International Nucleotide Sequence Database Collaboration (INSDC). Provision of nucleotide sequence data to ENA or its INSDC partners has become a central and mandatory step in the dissemination of research findings to the scientific community. ENA works with publishers of scientific literature and funding bodies to ensure compliance with these principles and to provide optimal submission systems and data access tools that work seamlessly with the published literature.

欧洲核苷酸档案（ENA）搜集并展示与基于核苷酸测序的实验流程相关的信息。一个典型的流程包括对测序材料的分离与制备、测序仪的运行以产生测序数据，以及随后的生物信息学分析流程。ENA将这些信息记录在一个数据模型中，该模型涵盖了输入信息（样本、实验设置、机器配置）、输出机器数据（序列轨迹、读数和质量分数）以及解读信息（组装、映射、功能注释）。数据来自多种来源，包括原始数据、组装序列和来自小型测序努力的注释提交，以及来自主要欧洲测序中心的数据提供和与国际核苷酸序列数据库合作组织（INSDC）合作伙伴的常规和全面交换。向ENA或其INSDC合作伙伴提供核苷酸序列数据已成为向科学界传播研究发现的中心且强制性的步骤。ENA与科学文献的出版商和资助机构合作，以确保遵守这些原则，并提供与发表文献无缝协作的优化提交系统和数据访问工具。