Gut microbes participate in food preference alterations during obesity

Obesity is associated with dysregulation in the hedonic food intake. Gut microbes are key players involved in obesity. Therefore, we investigated the causal role of gut microbes in hedonic food intake alterations contributing to obesity. We found out that the reduction of the pleasure induced by eating during obesity was transferable through gut microbiota transplantation. We also identified Parabacteroides as a potential actor involved in hedonic eating, probably through the gut-to-brain axis. These data provide evidence that gut microbes could be an interesting therapeutic target to tackle hedonic disorders related to obesity.