Whole genome sequences of P. falciparum evolved clones resistant multiple classes of antimalarial compounds

Whole genome sequences of evolved Plasmodium falciparum clones resistant to multiple small-molecule inhibitors. With this data, we showed that resistance alleles are likely to (1) be missense or frameshift, (2) involve bulky amino acid changes, and (3) occur in conserved domains, while CNV breakpoints originate in repetitive intergenic regions. We identified new likely multidrug resistance genes including pfzip1, and multiple transcription factors. Our data identifies features that predict multidrug resistance in malaria parasites.