H3K27ac and H3K4me1 histone mark profiles in term pregnant human myometrial tissues

Timely control of parturition is crucial for maternal and fetal health. Failures on this biological process often result in pregnancy complications including preterm birth, labor dystocia, and health disorders on newborn babies. The myometrium is the muscular structure of the uterus maintaining uterine structural integrity and providing contractile force for parturition. The myometrial structure changes in adaptation to the pregnancy via stage-specific transcriptomic profiles. Data from the mouse model indicate that changes of myometrial epigenomic landscape precedes the adoption of stage-specific gene expression pattern at term. The present study documents the transcriptomic profile and putative enhancer landscape of term pregnant myometrial tissues. Overall design: Term pregnant not in labor (TNL) human myometrial specimens from three healthy individuals were subject to the ChIP-seq assay to profile the genome-wide H3K27ac and H3K4me1 histone marks .