Outward-open structure of human glycine transporter 2 bound to allosteric inhibitor RPI-GLYT2-82

Outward-open structure of human glycine transporter 2 bound to allosteric inhibitor RPI-GLYT2-82 Descriptor: CHLORIDE ION, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ... Authors: Cantwell Chater, R.P, Peiser-Oliver, J, Pati, T.K, Quinn, A.S, Lotsaris, I, Frangos, Z.J, Anderson, K.E, Tischer, A.E, Williams-Noonan, B.J, Aubrey, K.R, O Mara, M.L, Michaelides, M, Mohammadi, S.A, Cioffi, C.L, Vandenberg, R.J, Shahsavar, A. Deposit date: 2024-12-22 Release date: 2026-02-25 Last modified: 2026-03-25 Method: ELECTRON MICROSCOPY (2.79 Å) Cite: A reversible allosteric inhibitor of GlyT2 alleviates neuropathic pain without on-target side effects. Biorxiv, 2025