Gene expression profiling identifies a gene signature that predicts progression to active tuberculosis several years before disease onset

We evaluated the predictive ability of various gene signatures in baseline peripheral blood mononuclear cell samples to distinguish Mtb-infected individuals who eventually progress to TB disease (progressors) or who remain asymptomatic (non-progressors) during clinical follow-up; we also compare long-term Mtb-infected non-progressors from patients with TB disease Overall design: Transcriptome profiles via RNAseq of progressors, non-progressors, and TB patients in a Brazilian household contact cohort were used to identify a gene signature predictive of progression to TB