Primary and secondary trial endpoints.

1Summarized as n (%) for proportion data and median (IQR) for time-to event data.2Estimate corresponds to the absolute risk difference (in%) for proportion data and a hazard ratio for time-to-event data.3p-values calculated by chi-squared test for proportional data and by Cox Regression models for time-to-event data.4Time-to-event endpoints calculated from study enrolment (i.e. the first dose of study treatment) unless mentioned otherwise.