Risk and Outcomes are Associated with Pathogenic Germline Variation in DNA Repair Genes in Multiple Myeloma

First-degree relatives of multiple myeloma (MM) patients are at increased risk for MM and other cancers, but the contribution of pathogenic germline variants (PGVs) in hereditary cancer (HC) genes to MM risk and outcomes is unknown. High/moderate-penetrance PGVs were significantly correlated with younger age at MM diagnosis and family history of cancer, and were independently associated with longer progression-free survival in patients treated with upfront high-dose melphalan and autologous stem cell transplantation