dominoSignal: data for a reproducible example

This repository hosts example data for reproducible analysis of intra- and intercellular signaling in single cell RNA sequencing (scRNAseq) data based on transcription factor (TF) activation. We demonstrate analysis using dominoSignal on the 10X Genomics Peripheral Blood Mononuclear Cells (PBMC) data set of 2,700 cells PBMC3K. scRNA-seq data is preprocessed following the Satija Lab's Guided Clustering Tutorial. Quantification of TF activation is conducted using pySCENIC. For more details on how this analysis is conducted, please refer to the vignettes in the dominoSignal package.