Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function. Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function

We used bulk and single-cell ATAC-seq to measure chromatin accessibilty in human kidneys. This allowed us to define candidate cis-regulatory elements of each human kidney cell type and identify the role of podocyte and tubule regulatory elements in human kidney function. Overall design: Single cell ATAC-sequencing of 3 human kidneys. Single cell ATAC-sequencing was performed on cortex from all 3 kidneys and medulla from two of the kidneys. Bulk ATAC-sequencing from the cortex of one human kidney was also performed. **Please note that the records have been updated with additional data on Aug 8, 2024.****