MeRIP-seq analysis of the spinal cord in the mice chronic constriction injury model of neuropathic pain

To search for novel m6A-modified transcripts that are involved in the genesis of neuropathic pain, We collected the ipsilateral spinal cord at 7 days after chronic constriction injury and performed m6A peak profiling using MeRIP-seq The m6A peak profiles of the transcripts in spinal cord from the chronic constriction injury group mice and sham group mice were measured at 7 days after operation

为筛选参与神经病理性疼痛发生的新型N6-甲基腺嘌呤（m6A）修饰转录本，本研究收集了慢性压迫性损伤造模后7天的小鼠同侧脊髓组织，采用MeRIP-seq开展m6A峰谱分析，检测了术后7天慢性压迫性损伤组与假手术组小鼠脊髓中转录本的m6A峰谱。

搜集汇总

背景与挑战

背景概述

该数据集是一个关于小鼠慢性压迫损伤神经病理性疼痛模型中脊髓的MeRIP-seq分析研究，旨在通过高通量测序技术探索m6A修饰在疼痛发生中的作用。数据集比较了损伤组和假手术组在手术后7天的m6A峰谱，包含4个样本，并提供了相关的甲基化峰数据和分析结果。