Photodynamic therapy-induced unfolded protein response
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Photodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, and ATF4. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3613 CPTAC Assay Portal]
光动力疗法可能诱发由转录因子热休克因子1(HSF1)、X-box结合蛋白1(XBP1)、激活转录因子(ATF)6以及ATF4介导的蛋白质毒性应激反应。该通路上的蛋白质具有可通过[https://assays.cancer.gov/available_assays?wp_id=WP3613 CPTAC 测定门户]获取的靶向测定方法。
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