Genome wide RNA-seq of wild-type iBMDMs upon HSV-1 infection.. Genome wide RNA-seq of wild-type iBMDMs upon HSV-1 infection.

Genome wide RNA-Seq screen was did to detect gene expression. We used immortalized bone-marrow-derived macrophages cells that were uninfected or infected with HSV-1 for 6 hours to detect the expression levels of genes, and we found that interferon stimulated genes were increased and some of genes that inhibit interferon production were decreased in HSV-1 infected iBMDMs, compared to wild-type iBMDMs. we choose some genes that are unknown about their functions on antiviral innate immunity, and adress how they participate in antiviral innate immunity. Overall design: Wild-type iBMDM were infected with HSV-1 for 6 hours, and then genome wide RNA-Seq screen to detect the expression of genes.